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As you know, parasites compete with
cattle for nutrition, suppressing dry matter
intake and decreasing average daily gain,
meaning they literally suck profit from your
operation.2 Which is one reason effective
parasite control is critical for cattle
performance and profitability.
But did you know that parasites directly
suppress the immune system, decreasing
the animal’s ability to fight infection or
respond to vaccines?
All these reasons are why choosing a
dewormer – or two – is an important decision.
Two? Yes. Parasite researchers now
recommend using two classes of dewormers
(typically one benzimidazole and one macrocyclic
lactone) for both effectiveness and to help
curb dewormer resistance issues.1
Use of Safe-Guard® exceeds the 90% reduction goal as measured by FECRT testing.3
0% 40% 50% 60% 70% 80% 90% 100%
This is why it is important to look beyond
brand names and active ingredients and
choose products from different classes.
Expert opinion now suggests that if you’re using
a dewormer with an active ingredient that
ends in “-ectin,” you should choose another
product with an active that ends in “-zole.”5
This also ensures that you’re getting both
tough internal parasites which “-zoles” like
Safe-Guard® (fenbendazole) excel at, including
brown stomach worm (Ostertagia), small
intestinal worms (Cooperia) and threadneck
worms (Nematodirus), as well as the internal
and external parasites that endectocides cover.
*Macrocylic lactones can also be broken down into
avermectins and milbemycins but are still the same class.
Widespread use of endectocides over the
last 40 years has contributed to a growing
resistance concern. Resistance to one brand
or compound of endectocide may cause
resistance to other members of the same
class. This is primarily because resistance to
one particular compound/brand may cause
resistance to other members of the same
class. This is known as side resistance.
A Case for Adding Safe-Guard1
**As measured by the National Fecal Egg Count Reduction
Put Your Dewormer to the Test
Of course, whatever deworming program
you’re using, you need to check that it’s
working. The fecal egg count reduction test
(FECRT) is the gold standard in efficacy
testing on live animals. It will not only tell you
which parasites you’re dealing with, but also if
they’re responding to your current program.
Proper parasite management is the
cornerstone of your animal health program.
That’s why understanding which products
belong to which class and consulting with
your veterinarian can help producers make
the right herd health decisions and aid in the
development of parasite control programs
that help achieve your operational goals.
Improving your deworming program doesn’t have to be
difficult. By adding Safe-Guard, you can kill more of those
microscopic monsters than you could with ivermectin alone.
When two dewormers
are better than one.1
Double Down on Resistance
(look for the “-zole”)
Macrocyclic Lactone (ML)
(look for the “-ectin”)*
Work as a purge wormer
in the gut, killing the
parasites in the animal at
the time of deworming.
Enter the bloodstream
through injection or
through the skin (pour-on)
to provide residual control.
Pour-On Alone 45.9%
Injectable Alone 39.4%
Safe-Guard Alone 98.7%
Safe-Guard + Ivermectin/
AVERAGE % EFFICACY
Safe-Guard® Plus an Avermectin
1Reinhardt, et al. A fenbendazole oral drench in addition to
an ivermectin pour-on reduces parasite burden and improves
feedlot and carcass performance of finishing heifers compared
with endectocides alone. J Anim Sci. 2006;84(8):2243-2250.
2Lawrence JD, Ibarburu MA. Economic analysis of pharmaceutical
technologies in modern beef production. Proceedings of the
NCCC-134 Conference on Applied Commodity Price Analysis,
Forecasting, and Market Risk Management. 2007;1-18.
3Merck Animal Health National FECRT Database.
4Coles, et. al. WAAVP methods for the detection of anthelmintic
resistance in nematodes of veterinary importance. Vet Parasitol.
5Data on file, Merck Animal Health.